Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media

Inclusion Criteria: * Clinical Diagnosis of Acute Otitis Media * Moderate to severe pain * Normally active and in good health as determined by the PI * Parent or legal guardian consent * Caregiver available to complete diaries during study Exclusion Criteria: * History of or current Perforated tympanic membrane * Tympanostomy tubes * Acute or chronic otitis externa * seborrheic dermatitis * Received any otic topical or systemic antibiotic within 14 days of enrollment * Receiving medication on a chronic basis for pain * Known hypersensitivity to investigational product. * clinical significant mental illness as determined by the PI * Exposed to another investigational agent within 30 days before study entry. Any condition the PI believed will interfere with the ability to comply with all study procedures * History of glucose 6-phosphate dehydrogenase deficiency * History or currently anemic * Congenital methemoglobinemia * Recent history of acute gastroenteritis within 14 days of enrollment