The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma (NCT02002754) | Clinical Trial Compass
UnknownPhase 4
The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma
China45 participantsStarted 2012-06
Plain-language summary
This study aim is to observe the response to Bambuterol Hydrochloride tablets treatment in subjects with eosinophilic bronchitis .
The investigators hypothesize:
A few of subjects with EB have some responses to Bambuterol Hydrochloride tablets therapy.
Most of subjects with CVA respond well to Bambuterol Hydrochloride tablets therapy
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Patients who have a history of cough as sole or main symptom lasting more than 8 weeks.
✓. Patients whose chest x-ray outcome was normal or without any active focus.
✓. Patients with eosinophilic bronchitis who were diagnosed with the result of sputum eosinophil percentage (Eos%) over 2.5%, and the negative result in bronchial provocation test by methacholine inhalation challenge.
✓. Patients with cough variant asthma have positive result in bronchial provocation test.
✓. Patients who was aged from 18 years old (≥ 18 years old ) to 75 years old (≤ 75 years old).
Exclusion criteria
✕. Patients who is a smoker or ex-smoker and has smoked within the previous year or has a cumulative smoking history \>10 pack-years or equivalence.
✕. Female subjects who are pregnant, breast-feeding or risk of becoming pregnant during the study.
✕. Subjects who are diagnosed with past or present disease, which as judged by the investigator, may affect the outcome of this study. These diseases include, but are not limited to, cardiovascular disease, malignancy, hepatic disease, renal disease, haematological disease, neurological disease, endocrine disease or pulmonary disease. e.g.nasal-sinus infection, lower respiratory tract infection, chronic bronchitis, emphysema, bronchiectasis, cystic fibrosis or bronchopulmonary dysplasia.
What they're measuring
1
Day-time and night-time cough symptom total-score changes from baseline to day 3.
Timeframe: three days
Trial details
NCT IDNCT02002754
SponsorThe First Affiliated Hospital of Guangzhou Medical University