Active — Not RecruitingNot Applicable

Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)

United States49 participantsStarted 2013-09-30

Plain-language summary

This study will use advanced MRI techniques to characterize the changes that occur to the structure and functionality of the brain in older breast cancer patients receiving adjuvant chemotherapy, and determine the relationship between the brain changes and severity of chemotherapy toxicity. Our results will be an early step towards identifying neuroimaging markers of aging, breast cancer and chemotherapy treatment, and will contribute to our understanding of the underlying pathophysiology of cognitive changes and chemotherapy toxicity in vulnerable, older adults with cancer. Furthermore, the work will lay the foundation for future, larger scale clinical studies of cognitive changes and chemotherapy toxicity in the aging cancer population.

Who can participate

Age range65 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 1\) Patients with stage I-III breast cancers who are to receive adjuvant chemotherapy; * 2\) Able to understand English (the functional MRI task paradigms and neurocognitive testing are not validated in languages other than English); * 3\) Able to provide informed consent; * 4\) Patients age ≥ 65 and of any performance status. Exclusion Criteria: * 1\) Patients with metastatic disease; * 2\) Patients with MRI exclusion criteria such as claustrophobia, cardiac pacemaker, and orbital metal implants.

What they're measuring

Intensity of brain activation during functional brain MRI.

Timeframe: 2 years

Trial details

NCT IDNCT01992432

SponsorCity of Hope Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-11-30

View on ClinicalTrials.gov More Breast Cancer trials