Tertiary Prevention by Exercise in Colorectal Cancer Therapy

Inclusion Criteria: * histologically confirmed nonhereditary primary Stage II or III colon cancer diagnosis or rectal cancer * written informed consent in German * histopathologically confirmed R0-resection * start of guideline conformed adjuvant chemotherapy within 12 weeks after R0-resection in Stage III colon cancer diagnosis (if necessary in Stage III colon cancer diagnosis) Exclusion Criteria: * hereditary colon cancer diagnosis * R1 and R2 resection * clinically relevant complications during recovery * secondary neoplasm * non-continuance of guideline conformed therapy * uncontrolled infection * manifest cardiac disease (e.g. unstable CAD, heart failure (NYHA IV), malignant hypertension) * clinical relevant respiratory disease (GOLD IV) * musculoskeletal disorders severely restricting the patients mobility (e.g. gonarthrosis, coxarthrosis) * cirrhosis of the liver (Child B and C) * Karnofsky performance status scale ≤ 60% * maximal exercise capacity ≤ 50 watt * clinically relevant lab factors (leukocyte count ≤ 3000/μl, thrombocyte count ≤ 20.000/μl, hemoglobin \< 8 g/dl) * physical activity level ≥ 18 MET-h/ week at screening