Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases

Inclusion Criteria: * age \> 18 year * male or female * documented diagnosis of one AIID among the 14 diseases selected (following consensual specific criteria) * stable or moderately active disease (except Lupus) under standard treatment (≥ 2 months) at the time of inclusion (except Sclerosing Cholangitis, Gougerot-sjögren, Takayasu's Disease and Systemic Sclerosis) * normal thyroid function (with or without treatment) * effective contraception for more than two weeks at inclusion and negative beta HCG test for women of childbearing potential, * affiliated to the social security system * written informed consent form. Exclusion Criteria: * known intolerance for IL2 (see SPC), * administration of a non-authorized treatment and/or IV bolus of corticosteroids in the last 2 months, * vaccination with live attenuated virus in the months preceding the inclusion or planned during the study * other severe or progressive autoimmune/inflammatory pathology, * low white blood cell count\<2000/mm3, lymphocytes \<600/mm3, platelets \<80 000/mm3, * heart failure (≥ grade III NYHA), renal insufficiency (Cockcroft\< 60ml/mn except patients with lupus or Wegener's granulomatosis) or hepatic insufficiency (transaminases\> 5N except for patients with autoimmune hepatitis), or lung failure, * significant abnormality in chest X-ray other than these linked to the diseases under investigation * cancer or history of cancer cured for less than five years (except in situ carcinoma of the cervix or …