Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer

INCLUSION CRITERIA: * Increased risk for breast cancer based on family history, personal history * Normal mammogram, clinical breast examination in the past 12 months * \>1 year from pregnancy, lactation or chemotherapy * Body mass index (BMI) between 25 - 40 EXCLUSION CRITERIA: * Concurrent malignancy or metastatic malignancy of any kind * Ongoing chemotherapy, radiation therapy, or other cancer-related treatment * History of a bleeding tendency or current use of Coumadin or other anticoagulants * Current or previous history of liver, gastrointestinal, hematopoietic, cardiac or renal disease, viral, bacterial, atypical or fungal infections of any organ system and human immunodeficiency virus (HIV) infection * Pregnant or lactating women * Concurrent use of hormonal contraception or hormone replacement therapy * Concurrent use of immunosuppressant medications * Concurrent use of medications known to inhibit or induce hepatic enzyme cytochrome P450 (CYP) 3A4 * Barriers to fine needle aspiration sampling of breast adipose, including breast implants, history of radiation to both breasts, bilateral mastectomies, and/or insufficient breast adipose tissue for adequate fine needle aspiration (FNA) sampling * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, hypertension, or psychiatric illness/social situation that would limit compliance with study requi…