STem cElls Mobilization in Acute Myocardial Infarction Outcome Trial

Inclusion Criteria: * Patients affected by acute anterior ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) or PCI-rescue with persistent occlusion of coronary artery, * Time symptom-to-balloon (≥3 h and ≤12h or ≤24 h if symptoms persist), * Thrombolysis in Myocardial Infarction (TIMI) flow post PCI ≥2, * Evidence of left ventricular (LV) dysfunction (EF biplane ≤45%) ≤24 h after revascularization, * Men and women aged ≥18 years and ≤75 years, * Informed consent must be signed before proceeding with any study procedure. Exclusion Criteria: * Previous anterior MI, * Recent MI (within 1 month), * Known previous LV dysfunction (EF \<45%), * Patients with angiographic evidence of coronary anatomy not suitable for PCI, or needing coronary artery bypass grafting (CABG), * Valve disease requiring surgical correction, * History of previous cardiac surgery or PCI on LAD within 6 months, * Previous or current documented history of leukemia, myeloproliferative or myelodysplastic disorder, * Previous or current documented history of malignant disease, * Haemoglobin \<10 mg/dl, * White blood cells (WBC) \>25.000 mm3, * Platelet \<50.000 mm3, * Sepsis, * Known HIV infection, * Immune system diseases, * Interstitial lung disease * Serious concomitant medical conditions (other than ischemic heart disease), * Pregnancy and breast feeding, * Documented alcohol and drug abuse, * Anticipated poor compliance. * Current participation in a cli…