Effect of Neuromuscular Block and Arterial PCO2 on Surgical Rating Scale (SRS), Following Reversa… (NCT01968447) | Clinical Trial Compass
CompletedNot Applicable
Effect of Neuromuscular Block and Arterial PCO2 on Surgical Rating Scale (SRS), Following Reversal With Sugammadex
Netherlands40 participantsStarted 2014-02
Plain-language summary
The purpose of this study is to study the effect of variations in the arterial CO2 concentration during deep neuromuscular block on the surgical conditions as assessed by the surgical rating scale
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* (i) Patients diagnosed with renal or prostatic disease who are will undergo an elective laparoscopic renal surgical procedure or laparoscopic prostatectomy;
* (ii) ASA class I-III
* (iii) \> 18 years of age;
* (iv) Ability to give oral and written informed consent.
Exclusion Criteria:
* (i) Known or suspected neuromuscular disorders impairing neuromuscular function;
* (ii) Allergies to muscle relaxants, anesthetics or narcotics;
* (iii) A (family) history of malignant hyperthermia;
* (iv) Women who are or may be pregnant or are currently breast feeding;
* (v) Renal insufficiency, as defined by serum creatinine x 2 of normal, or urine output \< 0.5 ml/kg/h for at least 6 h. When available, other indices will be taken into account as well such as glomerular filtration rate \< 60 ml/h and proteinuria (a ratio of 30 mg albumin to 1 g of creatinine).
* (vi) Previous retroperitoneal surgery at the site of the current surgery.
* (vii) Body mass index \> 35 kg/m2
* (viii) Chronic obstructive pulmonary disease GOLD 2-4 or a FEV1 less than 70% predicted or VC less than 70% predicted
* (ix) chronic pulmonary disease with altered lung physiology (eg. sarcoidosis, cycstic fibrosis, obstructing pulmonary tumors, previous lung surgery)