Topical Aprepitant in Prurigo Patients

Inclusion Criteria: * Patient with Prurigo suffering from chronic pruritus * Disease duration \> six month * Therapy refractory to at least two previous antipruritic treatments with topical, intralesional or systemic corticosteroids, or other immunosuppressants, antihistamines, antipsychotics, antidepressants, anticonvulsants and/or UV-irradiation * Adult male or female patients, aged 18 to 80 years Exclusion Criteria: * Concomitant medications that are primarily metabolized through Cytochrome P450 3A4 * Applied topical antihistamines, corticosteroids or mast cell stabilizers to the skin less than 3 weeks prior to Visit 1 (Screening) or during the course of the trial * UV-irradiation during the last 6 weeks prior to Visit 1 (Screening) * Prescribed systemic medications are limited * Clinically significant abnormalities in Blood analyses * Anamnestic excessive use of alcohol or tobacco or drugs * Presence of active tumor disease or history of malignancies within five years prior to Visit 1 (Screening) * Known or suspected hypersensitivity to component(s) of investigational products * Within the last 30 days or current participation in any other interventional clinical trial * Subjects who have received treatment with any non-marketed drug substance (i.e., an agent which has not yet been made available for clinical use following registration) within the last 6 month * Previously enrolled/randomised in this clinical trial * In the opinion of the investigator, the subject is u…