Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency

Inclusion Criteria: * patients aged 18 to 80 years with chronic venous insufficiency regardless of etiology stages 3 or 4 according to the CEAP classification (Clinical severity, Etiology or cause, Anatomy, Pathophysiology) * Patients available to participate in a 3 weeks session in the spa center and to be followed for 6 months Exclusion Criteria: * pregnant women, * contra-indication for the spa treatment (chronic infectious diseases, cancer, heart failure, serious liver or kidney disease, open leg ulcer, psychiatric disorders, immune deficiency, phlebitis, erysipelas or history of erysipelas); * surgery in the next three months, * spa treatment in the previous 6 months, * professional involvement with a spa resort