Evaluation of Potential Allergenicity of New Soybean Varieties

Inclusion Criteria: * Age 6 months to 40 years of any sex and any race * A convincing history of allergic reaction to soybean and a positive ImmunoCAP (\>0.35 kU/L) and/or a positive skin prick test to soy. Subjects should have ImmunoCAP repeated (if not done within the last 6 months) at National Jewish Health. * One of the following: A) Recent (within one year) failed open OFC B) Positive DBPCFC to soy at NJH; or C) Recent (within one year) exposure to soybean resulting in immediate IgE-mediated allergic symptoms (within 2 hours of ingestion; symptoms such as urticaria, angioedema, congestion, rhinorrhea, wheezing). * Written informed consent from parent/guardian and assent (when age appropriate). * Willingness to submit specimen for laboratory serum IgE testing * Willingness to submit lab specimen for ELISA testing Exclusion Criteria: * Inability to discontinue antihistamines for skin prick testing and OFCs * Current allergy to placebo ingredient (oat flour) OR reaction to any dose of placebo at the qualifying OFC * FEV1 value \<80% predicted or any clinical features of moderate or severe persistent asthma, as defined by the 2007 NHLBI guidelines table for classifying asthma severity (Step 3 or above), and greater than high daily doses of inhaled corticosteroids, as defined by the 2007 NHLBI guidelines inhaled corticosteroid dosing table (500 μg fluticasone or equivalents for an adult) * Asthma requiring either: \> 1 hospitalization in the past year for asthma or \> 1…