Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers

Inclusion Criteria: * PRE-REGISTRATION INCLUSION CRITERIA * Ability to understand and willingness to sign a written informed consent document and follow study procedures * Willingness to abstain from grapefruit juice, alcohol, and concomitant medications during study * Willingness to employ adequate contraception for men and women of childbearing potential; acceptable methods include double barrier methods, intrauterine device (IUD), postmenopausal status documented by serum follicle-stimulating hormone (FSH), and/or documentation of surgical sterilization * Body mass index \< 35 kg/m\^2 * Willingness to provide blood and tissue specimens for research purposes * REGISTRATION INCLUSION CRITERIA * Participants must have normal organ function and have normal laboratory findings without clinically significant findings * Satisfactory anesthesia and intestinal preparation, with no findings of advanced adenoma, chronic inflammation, or cancer Exclusion Criteria: * PRE-REGISTRATION EXCLUSION CRITERIA * Previous personal history of advanced adenomas (\>= 1 cm in maximal diameter, \>= 3 in total number, villous morphology, or high-grade dysplasia) or colorectal cancer * Family history of polyposis syndrome (e.g., familial adenomatous polyposis \[FAP\], hereditary non-polyposis colorectal cancer \[HNPCC\]) or colorectal cancer (first degree relatives younger than 60 years old) * History of gastroparesis * History of surgery involving the luminal gastrointestinal (GI) tract, including…