Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF

Inclusion criteria

• ✓. Subjects with renal failure (defined as creatinine ≥ 2.0 to ≤ 3.4 mg/dL)
• ✓. Subjects with other single organ failure with i. Renal impairment (defined as an increase in creatinine of \> 0.3 mg/dL from either an established prior Baseline level or if applicable, upon admission to hospital if prior level is unavailable; for inclusion, the creatinine level must be raised above normal levels), and/or ii. Hepatic encephalopathy grade I or II
• ✓. Subjects with two organ failures