Acarbose and Older Adults With Postprandial Hypotension (NCT01914133) | Clinical Trial Compass
CompletedPhase 2
Acarbose and Older Adults With Postprandial Hypotension
Canada42 participantsStarted 2014-01
Plain-language summary
The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of blood pressure after eating), which can result in falls.
Who can participate
Age range65 Years
SexALL
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Inclusion Criteria:
* be 65 years of age or older,
* be a non-smoker for at least 5 years
* be referred to the falls clinic at Vancouver General Hospital
* have a Folstein test of cognition \> 25/30 to ensure meal log-book compliance
Exclusion Criteria:
* no oral or swallowing issues that would prevent a Meal Test
* subject requiring dialysis due to end-stage renal failure will be excluded
* subjects with evidence on history, physical or blood work of hepatic disease will be excluded since elevated serum transaminases are a potential adverse effect of acarbose
* cannot currently be taking an alpha-glucosidase inhibitor
* cannot have had allergic reactions to alpha-glucosidase inhibitors in the past
* Due to the fact that acarbose is renally excreted, all subjects must have a Creatine Clearance of greater than 25 ml/min
* Subjects with a past history of inflammatory bowel disease, intestinal obstruction, ileus and peptic ulcer disease will be excluded
* Subjects taking carbohydrate-splitting enzymes (such as amylase) will be excluded
* Subjects with chronic respiratory issues requiring treatment will be excluded
What they're measuring
1
The postprandial cardiovascular response to a standardized meal compared between subjects with and without PPH