Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder (NCT01912391) | Clinical Trial Compass
CompletedPhase 3
Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder
United States30 participantsStarted 2012-10
Plain-language summary
Selegiline is superior to placebo in improving psychological and physical functioning in patients with Borderline Personality Disorder.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Subject has primary diagnosis of Borderline Personality Disorder(BPD).
* Subject has Symptomatology of BPD for at least 1 year.
* Subject understands the study procedures and voluntarily agree to participate.
* Subject is able to read, understand and complete questionnaires.
* Subject agrees to use (2)acceptable forms of contraception throughout the study.
* Patient must have a screening SCL 90-R score of \> 120 (range 0-360).
Exclusion Criteria:
* Subject is not pregnant or breast feeding.
* Subject is unlikely to adhere to the study procedures and restrictions.
* Patient has failed treatment due to lack of efficacy of monoamine oxidase inhibitor(MAOI) medication.
* Patient anticipates need for surgery during the study.
* Patient has another predominant personality disorder other than BPD.
* Subject has an active history of substance abuse or dependence, e.g.,Positive Drug screen
* Subject has other health issues which could interfere with study interpretation.
* Subject reports recent suicide attempts or homicide attempts in the past 3 months.
* Subject must be substance abuse or dependence clean for (1) year.
* Subject has a history of a primary malignancy \< 5 yrs.
* Subject has a medical condition(s)that are excluded, per Protocol, or are unstable.
* Subject has abnormal screening laboratory values, per Protocol, or other clinically significant, unexplained laboratory abnormality.
* Subject is currently participating or has participated in a stud…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Primary Efficacy Measurement: Changes in the Hopkins Symptom Checklist 90-Revised (SCL 90-R) scale