This open-label, multicenter study will evaluate the pharmacokinetics, safety and efficacy of vemurafenib in Chinese participants with BRAF V600 mutation-positive unresectable or metastatic melanoma. Participants will receive vemurafenib 960 milligrams (mg) orally twice daily until disease progression or unacceptable toxicity occurs.
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Area Under the Plasma Concentration-Time Curve (AUC) of RO5185426 From 0 to 8 Hours on Day 1
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8 hours) on Day 1
AUC of RO5185426 From 0 to 8 Hours on Day 21
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8 hours) on Day 21
AUC of RO5185426 From 0 to 12 Hours on Day 1
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12 hours) on Day 1
AUC of RO5185426 From 0 to 12 Hours on Day 21
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12 hours) on Day 21
Maximum Plasma Concentration (Cmax) of RO5185426 on Day 1
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12 hours) on Day 1
Cmax of RO5185426 Following Day 21 Dose
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12, 24, 28, 72, 76, 168 hours) from Day 21
Time of Maximum Plasma Concentration (Tmax) of RO5185426 on Day 1
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12 hours) on Day 1
Tmax of RO5185426 Following Day 21 Dose
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12, 24, 28, 72, 76, 168 hours) from Day 21
AUC From 0 to 168 Hours of RO5185426 Following Day 21 Dose
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12, 24, 28, 72, 76, 168 hours) from Day 21
Elimination Half-Life (t1/2) of RO5185426 Following Day 21 Dose
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12, 24, 28, 72, 76, 168 hours) from Day 21
Trough Plasma Concentration (Ctrough) of RO5185426 on Day 15
Timeframe: Pre-dose (0 hours) on Day 15
Ctrough of RO5185426 on Day 19
Timeframe: Pre-dose (0 hours) on Day 19
Ctrough of RO5185426 on Day 21
Timeframe: Pre-dose (0 hours) on Day 21
Accumulation Ratio of RO5185426 AUC From 0 to 8 Hours Between Day 21 and Day 1
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8 hours) on Days 1 and 21
Terminal Elimination Rate Constant (Kel) of RO5185426 on Day 21
Timeframe: Pre-dose (0 hours) and post-dose (1, 2, 4, 5, 8, 12, 24, 28, 72, 76, 168 hours) from Day 21