Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma

Inclusion Criteria: * Diagnosis of locally advanced, unresectable or metastatic cutaneous melanoma or unknown primary melanoma (AJCC Stage IIIB, IIIC, or IV) * Presence of BRAF V600E or V600K mutation in tumor tissue prior to randomization * Naïve untreated patients or patients who have progressed on or after prior first line immunotherapy for resectable locally advanced or metastatic melanoma; prior adjuvant therapy is permitted (e.g. IFN, IL-2 therapy, any other immunotherapy, radiotherapy or chemotherapy), except the administration of BRAF or MEK inhibitors * Evidence of at least one measurable lesion as detected by radiological or photographic methods * ECOG performance status of 0 or 1 * Adequate bone marrow, organ function, cardiac and laboratory parameters * Normal functioning of daily living activities Exclusion Criteria: * Any untreated central nervous system (CNS) lesion * Uveal and mucosal melanoma * History of leptomeningeal metastases * History of or current evidence of central serous retinopathy (CSR), retinal vein occlusion (RVO) or history of retinal degenerative disease * Any previous systemic chemotherapy treatment, extensive radiotherapy or investigational agent other than immunotherapy, or patients who have received more than one line of immunotherapy for locally advanced unresectable or metastatic melanoma; Ipilimumab (adjuvant) or other immunotherapy treatment must have ended at least 6 weeks prior to randomization * History of Gilbert's syndrome * Pr…