Hepatic Safety of Currently Used Antiretroviral Regimens in Patients With Chronic Hepatitis Under Real Life Conditions

Inclusion Criteria: * Older than 18 years * HIV-1 infection as confirmed by ELISA and western blot * Chronic HCV infection as confirmed by HCV antibodies in plasma, as well as a positive HCV viral load determined by polymerase chain reaction OR chronic hepatitis B infection as confirmed by HBsAg * Treatment-naive or pretreated patients who start a new antiretroviral regimen that includes at least one drug that has not been received by the patient before * At least one week of exposure to new regimen * Liver biopsy or transient elastometry determination within 12 months prior to treatment initiation Exclusion Criteria: * Pregnancy * Treatment against hepatitis C virus infection * Presence of opportunistic infections, including tuberculosis, neoplasia, autoimmune diseases. Patients receiving primary or secondary chemotherapy against an opportunistic process are not included. * Any liver disease of vascular, metabolic, biliary, autoimmune or tumoral origin * Patients who are not able to provide written informed consent to participate in the study * Lack of scheduled clinical visits including blood analysis throughout study period