Bone Reconstruction of the Skull Using a Metal Ceramic Implant After Previously Failed Reconstruction

Inclusion Criteria: * Obtained informed consent. * Males or females, ≥18 years of age * Subject with cranial defect size \> 25 cm2. * History of previous cranial implant failure and where the latest cranial reconstruction failed within 12 months. (This means that the patient demonstrates a non-reconstructed cranial defect after removal of implant or exhibit an implant failure, e.g. local infection and/or protrusion through the skin.) * Willing and able to comply with all study procedures and restrictions. * The 5 subjects participating in bone regeneration analysis (PET/CT scans) has to be 50 years or older Exclusion Criteria: * Malignancy adjacent to the reconstruction area, including brain and calvaria, with on-going or planned surgical intervention. * Pregnant or nursing women. Exclusion criteria during surgery, if applicable: Perioperative appearance of previously not identified tumor or infection in the reconstruction area.