CompletedNot Applicable

Nicotine Metabolism and Little Cigars

United States197 participantsStarted 2012-12

Plain-language summary

This study examines the effects of smoking little cigars in different groups of smokers. The investigators are focusing on differences in how smokers' bodies break down and eliminate nicotine from their systems. Some people are fast metabolizers of nicotine, meaning they break down and eliminate nicotine from their bodies more quickly. Other people are slower metabolizers meaning they break down and eliminate nicotine more slowly. The investigators are comparing these two groups of smokers when they switch to smoking cigars instead of cigarettes.

Who can participate

Age range21 Years – 65 Years

SexALL

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Exclusion criteria

✕. use of any nicotine containing products other than cigarettes
✕. current or impending enrollment in smoking cessation program
✕. history in the last year or current treatment of substance abuse (other than nicotine dependence)
✕. positive drug screen for cocaine or opiates for urine drug screen at intake session
✕. alcohol use greater than 25 standard drinks per week
✕. current or planned pregnancy or lactating
✕. history or current diagnosis of psychosis, bipolar disorder, mania, or schizophrenia
✕. current major depression (history of major depression but in remission for a minimum 6 months is eligible).

What they're measuring

Number of cigars consumed daily

Timeframe: 20 days

Trial details

NCT IDNCT01898559

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-10

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