Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia (NCT01898338) | Clinical Trial Compass
CompletedPhase 3
Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia
Spain167 participantsStarted 2013-12
Plain-language summary
To demonstrate that the combination of daptomycin and fosfomycin is superior to daptomycin alone in the treatment of methicillin resistant Staphylococcus aureus (MRSA) bacteremia.
Who can participate
Age range18 Years – 99 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with at least 1 positive blood culture to MRSA within 72h up to randomization
* Adult patients, equal or older than 18 years old
* Signed informed consent
* Mandatory use of contraception methods for fertile women during the study period and for 6 months after stopping antibiotic therapy
Exclusion Criteria:
* Polymicrobial bacteremia
* Pneumonia associated to the bacteremia
* Severe clinical status with expected survival of less than 24 hours
* Allergy to daptomycin or fosfomycin
* A positive pregnancy test at the time of inclusion
* Any clinical condition that requires additional antibiotic therapy with microbiological activity against MRSA
* Patient already included in another clinical trial
* Prior history of eosinophilic pneumonia
What they're measuring
1
Therapy response
Timeframe: at week 6 after end of therapy (an average of 8 to 12 weeks from the beginnig of therapy)