Efficacy and Safety of Everolimus in Liver Transplant Recipients of Living Donor Liver Transplants

Inclusion criteria: * Written informed consent * Subject aged ≥18 years of a primary, orthotopic liver allograft, from a living donor * Subject negative for HIV Incusion criteria at Randomization: \- Subject was initated on tacrolimus-based immunosuppressive regimen with steroids and other immunosuppression Exclusion criteria: * Subjects transplanted for acute liver failure * HCV negativesubjects receiving a transplant from HCV positive donor * Subjects receiving multiple solid organ (including multiple liver lobes/segments) or islet cell tissue transplants, or have previously received an organ or tissue transplant. * Subjects receiving an ABO incompatible allograft. * MELD-score \> 35 within 1 month prior to transplantation. * Use of immunosuppressive or antibody induction agents not specified in the protocol. * History of malignancy of any organ system (except hepatocellular carcinoma or localized basal cell carcinoma of the skin) * Hepatocellular carcinoma with extrahepatic spread or macrovascular invasion * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test. * Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and for 2 weeks after the last dose of study medication * History of hypersensitivity to any o…