Artemisinin-Based Antimalarial Combinations and Clinical Response in Cameroon

Inclusion Criteria: * Children of either gender, aged between 6 months (\> 5kg) and 10 years. * Suffering from acute uncomplicated P. falciparum malaria confirmed by microscopy using Giemsa-stained thick film with an asexual parasite density of 1,000 to 100,000 parasites/μl. * Presenting with fever (axillary temperature ≥ 37.5oC) or having a history of fever in the preceding 24 hours. * Able to ingest tablets orally (either suspended in water or uncrushed with food). * Willing to participate in the study with written assent from parent/guardian. Parental authorization will be obtained for children less than 8 years old and documented assent of parents/guardians for children 8-10 years. * Willing and able to attend the clinic on stipulated regular follow-up visits. Exclusion Criteria: •Any of the following "danger signs of severe malaria": Not able to drink or breast feed Persistent vomiting (\>2 episodes within previous 24 hours) Convulsions (\>1 episode within previous 24 hours) Lethargic/unconscious * Signs/symptoms indicating severe/complicated malaria according to WHO criteria (WHO definition). * Concomitant illnesses, underlying chronic hepatic or renal disease, abnormal cardiac rhythm, hypoglycaemia, jaundice, respiratory distress, * Serious gastrointestinal disease, severe malnutrition (W/H \< 70%) or severe anaemia (haemoglobin \< 5 g/dl). * Known hypersensitivity to the study drugs.