TerminatedNot Applicable

Validation of [18F]FES for Imaging of Brain Estrogen Receptors

Stopped: Not enough participants

Netherlands3 participantsStarted 2013-11

Plain-language summary

Validation of \[18F\]-FES for imaging of estrogen receptors in the brain The primary objective of the study is to determine if \[18F\]-FES Positron Emission Tomography (PET) can be used to quantify the estrogen receptor expression in the human brain.

Who can participate

Age range

18 Years – 65 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female * Age \> 18 years * For postmenopausal women: at least 1 year after menopause * For premenopausal women: a regular menstruation * Signed written informed consent Exclusion Criteria: * Use of estrogen receptor ligands, such as tamoxifen or fulvestrant * History of ER-positive malignancies or breast cancer * Use of any contraceptive drugs (pill, injections or implanted) * For postmenopausal women: (history of) estrogen replacement therapy * Pregnancy * History of removal of the ovaries and/or the uterus * Current systemic diseases * Major metabolic diseases (e.g. diabetes, hyper- or hypothyroidism) * Somatic, organic or neurological disorders * Recent participation in a scientific research study (\<1 year) involving radiation * Claustrophobia * Presence of materials in the body that can be magnetized, like: pacemaker, metallic implants/prostheses, metal fragments, shunts, artificial heart valves, vascular clips, fixed hearing aid, tattoos containing metal, hair implants, artificial dentures

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Quantification of estrogen receptors in the human brain

Timeframe: 1 year

Trial details

NCT IDNCT01842217

SponsorUniversity Medical Center Groningen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-01

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