The purpose of the study is to evaluate whether low-dose USP methylene blue (MB) will: i) improve short-term memory retention in a delayed match-to-sample task, ii) reduce reaction time in a psychomotor vigilance test, and iii) enhance responses to a visual-motor task as measured by functional magnetic resonance imaging (fMRI). A single low-dose MB or placebo will be orally administered to self-declared healthy adults using double-blind study design. Non-invasive fMRI data will be acquired before and after MB administration in the same subjects. Each study will take 2-3 hours, inclusive of an hour break in between.
Age range
18 Years – 65 Years
Sex
ALL
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Improvement in reaction time assessed by fMRI measurements and PVT measurements
Timeframe: 1 hour
Improvement in memory assessed by fMRI measurements and DMS measurements
Timeframe: 1 hour