By InvitationNot Applicable

Molecular Basis of Food Allergy

United States5,300 participantsStarted 2011-01

Plain-language summary

The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells, basophils and cytokines in the development of food allergy. The study also explores these factors in development of tolerance "outgrowing" food allergy. It will also explore the genetic factors that lead to the development of food allergy. The study examines all type of food allergy including IgE mediated reactions, Eosinophilic Esophagitis and Food Protein Induced Enterocolitis

Who can participate

Age range1 Month – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Males or females age 1 month to 65 years.
✓. Diagnosis of Food Allergy. Food Allergy can be either IgE or non-IgE mediated food allergy including Eosinophilic Esophagitis and Food Protein Induced Enterocolitis.
✓. Age and sex matched patients without food allergies
✓. Sibling and parents of patients with food allergies
✓. Age and sex matched patients without food allergies
✓. Sibling and parents of patients with food allergies
✓. Patients with atopy

Exclusion criteria

✕. Underlying disease or medical problem that is judged to serious or risky to allow 3 ml/kg of blood to be drawn from a vein (such as serious anemia, cancer, poor vein abscess, serious infections).
✕. Subjects that do not meet the enrollment criteria may not be enrolled. Any violations of these criteria will be reported in accordance with Institutional Review Board (IRB) policies and procedures study procedures.

What they're measuring

Blood sample for mechanistic studies:

Timeframe: 1 year

Blood sample for genetic study (optional)

Timeframe: 1 year

EndoPat Test (optional)

Timeframe: 1 year

Trial details

NCT IDNCT01832324

SponsorChildren's Hospital of Philadelphia

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-12

View on ClinicalTrials.gov More Food Allergy trials

Plain-language summary

Who can participate

Age range1 Month – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Males or females age 1 month to 65 years.
✓. Diagnosis of Food Allergy. Food Allergy can be either IgE or non-IgE mediated food allergy including Eosinophilic Esophagitis and Food Protein Induced Enterocolitis.
✓. Age and sex matched patients without food allergies
✓. Sibling and parents of patients with food allergies
✓. Age and sex matched patients without food allergies
✓. Sibling and parents of patients with food allergies
✓. Patients with atopy

Exclusion criteria

✕. Underlying disease or medical problem that is judged to serious or risky to allow 3 ml/kg of blood to be drawn from a vein (such as serious anemia, cancer, poor vein abscess, serious infections).
✕. Subjects that do not meet the enrollment criteria may not be enrolled. Any violations of these criteria will be reported in accordance with Institutional Review Board (IRB) policies and procedures study procedures.