CompletedPhase 4

Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS

United States89 participantsStarted 2013-03

Plain-language summary

This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels \< 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at the time of GnRH agonist trigger or adjuvant hCG 1,500 IU 35 hours after GnRH agonist trigger.

Who can participate

Age range18 Years – 39 Years

SexFEMALE

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Inclusion Criteria: * Normal baseline serum follicle stimulating hormone, polycystic ovarian syndrome (PCOS), Polycystic ovarian morphology, Previous high responder or previous OHSS, must have \> 14 follicles of over 11 mm in diameter and with peak serum E2 levels \< 4,000 pg/mL on the day of trigger of oocyte maturation. Exclusion Criteria: * Hypothalamic dysfunction, Patients with \< 14 follicles \< 11 mm in diameter, peak serum E2 levels \>= 4,000 pg/mL.

What they're measuring

Ongoing Pregnancy

Timeframe: Through time of study completion, on average 1-2years

Trial details

NCT IDNCT01815138

SponsorUConn Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-12

Results submitted2017-04-17

View on ClinicalTrials.gov More Ovarian Hyperstimulation Syndrome trials