Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease

Inclusion Criteria: * \- Age from 18 to 60 years old * Low back pain * Daily pain since at least 3 months * VAS for pain \> 40/100 during the last 48 hours * Inefficiency, intolerance, or contraindication to NSAIDS * Inefficiency of a rigid or half-rigid back brace * Modic 1 discopathy (diagnosed on MRI and confirmed by trained radiologist) * Dental check-up within the last 6 months * Signed informed consent Exclusion Criteria: * \- Static disorders of the spine * Contraindication to pamidronate (hypocalcemia, severe kidney failure, or allergy) * Underage patients, patients under the protection of the law * Previous treatment with bisphosphonates * Pregnancy * Local or general infection * Previous discal surgery * Systemic corticosteroid therapy in the last month * Epidural or facet joint corticosteroid injection in the last month * History of septic spondylodiscitis * Ankylosing spondylitis * Low back pain associated with radiculalgia * Active psychiatric disorder * Inability to read or understand French * Body temperature above 38°C (fever) or Erythrocyte Sedimentation Rate above 20mm/hour