Intralipid for Recurrent Miscarriage (NCT01788540) | Clinical Trial Compass
CompletedPhase 4
Intralipid for Recurrent Miscarriage
Egypt300 participantsStarted 2013-02
Plain-language summary
Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.
Who can participate
Age range18 Years – 40 Years
SexFEMALE
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Inclusion Criteria:
* Couples with unexplained secondary infertility
* Three or more prior consecutive clinical miscarriages after either spontaneous pregnancy or after IVF/ICSI.
* Elevated natural killer (NK) cells CD16, CD56 and cells with both CD16/CD56 \>12%.
Exclusion Criteria:
* Age above forty years old.
* Antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies \[IgG or IgM\]); other recognised thrombophilic conditions (testing according to usual clinic practice).
* Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy).
* Abnormal parental karyotype.
* Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).
* Disturbances of normal fat metabolism such as pathologic hyperlipemia
* Allergic to it; or to eggs, soybean oil, or safflower oil.
* Severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.