Alternative Access Approaches for Transcatheter Aortic Valve Replace (TAVR) in Inoperable Patients With Aortic Stenosis

Inclusion Criteria: * 18 years or older * Primary indication is symptomatic primary severe aortic stenosis predicted to benefit from relief of valvular stenosis * Aortic valve area less than 0.8 centimeters squared * Mean aortic valve gradient greater than or equal to 40 mmHG * Peak aortic jet velocity greater than or equal to 4.0 m per second * Valve sheath access site is femoral, axillary, transapical, transaortic, subclavian or subaxillary * Patient is judged by the local heart team to be inoperable for Aortic Valve Replacement due to severe chest wall deformities or radiation effects, severe peripheral or aortic vascular disease, or severe systemic disease prohibiting the safe conduct of Cardiopulmonary Bypass (CPB) Exclusion Criteria: * Aortic valve annulus size is less than 18 mm or greater than 25 mm * Active infectious endocarditis * Valve in prosthetic valve procedure * Patients considered by the heart team to be unlikely to receive meaningful or durable clinical benefit from the procedure