Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study

Inclusion Criteria * Provision of signed written informed consent which includes genetic consent. * Ability to comply with study procedures. * Males and females aged 40-70 years inclusive. * Have a body mass index (BMI) between 18 and 35 kg/m2 inclusive and minimum body weights of 50 kg. * Have a normal physical examination, and have normal laboratory values, 12-lead ECG and vital signs (blood pressure, heart rate and respiratory rate), unless the Investigator considers an abnormality as not clinically significant. * Ability to perform reproducible spirometry according to the American Thoracic Society and the European Respiratory Society (ATS/ERS) guidelines (American Thoracic Society, 2005). * Ability to produce a minimum 0.1 gram sputum sample after induction with inhaled hypertonic saline. Additional Inclusion Criteria COPD Group * A clinical diagnosis of COPD according to the GOLD guidelines (stage 1-2). * Current smokers with ≥10 pack-year smoking history. * Demonstrate a post-bronchodilator ratio between forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) of \<70 % and FEV1 ≥50 % of predicted normal. Additional Inclusion Criteria Non-Smokers Group * Have never smoked tobacco products. * Demonstrate normal lung function by post bronchodilator FEV1 ≥80 % of predicted normal, with no evidence of airway obstruction FEV1/FVC ratio ≥70 %. * Have a sputum eosinophilia \<2 % and a sputum neutrophilia \<80 % from the sample collected at visit 1 (Beld…