Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease (NCT01778465) | Clinical Trial Compass
CompletedNot Applicable
Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease
Canada7 participantsStarted 2013-05
Plain-language summary
Aspirin-Exacerbated Respiratory Disease, or AERD, consists of aspirin sensitivity, asthma and nasal polyps. It is currently managed by chronic steroid use, multiple endoscopic sinus surgeries and/or aspirin desensitization. However, these treatments have potential adverse effects.
A theory has been postulated that decreasing the level of dietary salicylates may help in long-term control of disease. A current trial is in the works to evaluate the clinical outcomes of decreased salicylate, but measurements of biochemical markers of disease has not yet been done. The hypothesis is that decreased dietary salicylates will result in a decrease in urinary salicylates and inflammatory markers of disease, cys-leukotrienes, which are typically elevated in this disease.
Who can participate
Age range
18 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* adult patients
* Aspirin-exacerbated respiratory disease
Exclusion Criteria:
* recent use of Prednisone or other systemic steroids (greater than 3 doses in past 3 months)
* Endoscopic sinus surgery or polypectomy within the past 6 months
* Other significant systemic disease, including renal failure, or immunocompromised state.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Urinary Levels of Cys-Leukotrienes
Timeframe: 14 days after commencement
2
Urinary Salicyluric Acid Levels
Timeframe: 14 days after commencement
3
Urinary Salicylic Acid Levels
Timeframe: 14 days after enrollment
4
Urinary Creatinine Levels
Timeframe: 14 days after commencement
Trial details
NCT IDNCT01778465
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's