This randomized phase II trial studies how well intravenous (IV) chemotherapy or oral chemotherapy works in treating patients with previously untreated stage III-IV human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, prednisone, lomustine, etoposide, and procarbazine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Overall Survival
Timeframe: Up to 24 months
Overall Response Rate
Timeframe: Up to 24 months
Progression-free Survival
Timeframe: Up to 24 months
Participants Who Experienced an Adverse Event
Timeframe: Up to 24 months
Number of Patients Who Complete Treatment
Timeframe: Up to 18 weeks
Proportion of Patients Who Are Adherent to Antiretroviral Therapy
Timeframe: Up to 24 months
Proportion of Patients Who Are Adherent to Chemotherapy
Timeframe: Up to 18 weeks
Change in Absolute CD4 Count From Baseline to Post-treatment
Timeframe: From baseline to 18 weeks