Safety Study of Bone Marrow Derived Stem Cells on Patients With Cutaneous Photoaging

Key Inclusion Criteria: * Males and Females 40-70 years of age * Good general health * Fitzpatrick skin type I-III * Fitzpatrick Wrinkle Scale class III. Fine to deep wrinkles, numerous lines with or without redundant skin folds * Ability to understand and provide signed informed consent * Reasonable expectation that subject will attend all scheduled safety follow-up visits * Reasonable expectation that subject will maintain skin care regimen for the duration of the trial * Adequate organ function Key Exclusion Criteria: * History of malignant neoplasm within the past 5 years, or Stage 3 or 4 of any cancer at any time * History of melanoma, leukemia, or lymphoma (any stage) * Persistent pre-cancerous lesions (e.g., actinic keratosis) * Active cutaneous infection of the head and/or neck * Active cutaneous neoplasm in the treatment area * Topical use of any anti-aging creams on the head and/or neck; if used, subject must agree to discontinue for the one year of follow-up on study * Cosmetic or surgical treatment on face/neck in 6 months before study (includes laser, chemical peels, fillers, botulinum toxin) * Prior treatment with stem cells * Positive for hepatitis B, C or HIV * Abnormal and clinically significant findings on screening ECG * Abnormal and clinically significant findings on screening CT scan of the chest (without contrast) * Clinically significant medical condition for which participation in the study would pose a safety risk to the subject * Major surgery wit…