Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer

Inclusion Criteria: * Unresectable, locally advanced measurable (at least bidirectional) adenocarcinoma of the pancreas (regardless of site) proven by biopsy or cytology and confirmed by surgical consultation * Informed consent and authorization for the release of health information signed by the patient * Karnofsky performance status \>= 70% * Life expectancy \>= 3 months * Females of childbearing potential and males must use an effective method of contraception Exclusion Criteria: * Metastatic (stage IV) disease (including involvement of the colon, adrenals, or kidney, or radiographic evidence of peritoneal seeding or pulmonary metastases) * Previous chemotherapy, radiotherapy of other treatment for PC * Gastric or duodenal wall invasion by the primary PC as assessed by CT or MRI and EUS staging * Gastric or duodenal ulcer (at least 10 mm in size) within 10 mm of expected endoscopy puncture site(s) for PDT * Esophageal or gastric varices * Cystic component \>= 25% the total volume of the tumor * Ascites detected by CT, ultrasound (US) or MRI; (trace ascites will not be an exclusion) * Bulky celiac adenopathy (i.e., \>= 2.5 cm in diameter) * Diagnosis of islet cell tumor, lymphoma, metastatic lesion, acinar cell (or other atypical pathologic malignancy) * History of other malignancy in the past 2 years except carcinoma in situ of the cervix or bladder, non-melanomatous skin cancer or localized/early stage prostate cancer * Unable to receive or previously intolerant of mod…