CompletedPhase 4

Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension

China109 participantsStarted 2010-11

Plain-language summary

β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent cardiovascular factors for hypertension. Hence, we analyzed the effects of bisoprolol and atenolol on SNA and CAP in hypertensive patients.

Who can participate

Age range25 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 25\~65 years old * untreated essential hypertension * SBP 140-160mmHg \& DBP 90-100mmHg * Sinus rhythm * Resting heart rate \>70bpm * Can give written informed consent Exclusion Criteria: * Atrial Fibrillation (AF)/ Sick Sinus Syndrome (SSS)/ atrioventricular block 2-3 grade(AVBⅡ-Ⅲ) without pacemaker * Bradyarrhythmia/ hypotensive * Unstable Angina Pectoris (UAP)/AMI/ HF (NYHA class III - IV) * Uncontrolled diabetes mellitus (DM) * Bronchial asthma * Gastro-intestinal ulcer or skin ulcer * Liver dysfunction/ renal impairment * Treated with CCB (Calcium antagonists) ( except amlodipine) or other beta blocker. * Glaucoma * Known allergic/ intolerance to beta blocker * Pregnant or lactating women * Participation in another clinical study within the last 3 months * Legal incapacity or limited legal capacity

What they're measuring

baroreflex sensitivity

Timeframe: 4~8 weeks

central aortic pressure

Timeframe: 4~8 weeks

Trial details

NCT IDNCT01762436

SponsorRuijin Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-02

View on ClinicalTrials.gov More Untreated Essential Hypertension trials