Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging (NCT01737606) | Clinical Trial Compass
CompletedNot Applicable
Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging
France53 participantsStarted 2012-09
Plain-language summary
The new technical of ultrasonic exploration of this project purpose to validate the measurement of cerebral pulsatility by a new way called "Fast Cerebral Pulsatility Imaging" (FCPI).This will somehow determine the natural history of cerebral pulsatility during development adult to old age
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Patient at least 18 years old
* Informed consent form signed
* Person affiliated to a medical insurance
* Male or female
* No smoking the day of the inclusion
* Right handed: Edinburgh test ≥0.8 (subjects of phase 2)
* MMS score ≥ 27 and 5 words score = 10 (subjects of phase 2)
* Socio-educational level greater than or equal to 8 years of school (subjects of phase 2)
Exclusion Criteria:
* Pregnant women, lactating women or women without reliable contraception
* Contraindications to IRM for patients with: ocular metallic foreign object; any electronic medical device implanted by irremovable way (pacemakers, neuro-stimulator, cochlear implants ...); metallic heart valve, old heart valves are specially an absolute contraindication because of risk of dysfunction; vascular clips implanted formerly on brain aneurysm
* Acute medico-surgical condition dating from less than 3 months
* Neurological and neuro-surgical pathology such as: toxic, infectious or inflammatory encephalopathy, epilepsy, intracranial arteriovenous malformation known, intracranial tumor or hydrocephalus known, operated or no, history of ischemic or hemorrhagic stroke, transient or not
* Treatments or pathology that could influence the results of the research: heart failure (dyspnea with stage III or IV NYHA) or non-sinus cardiac rhythm, use of central analgesics or psychotropic drugs
* Psychiatrics disorders of axe 1 of DSM IV, based on MINI (subjects of phase 2)
* Major subject with a le…
What they're measuring
1
Phase 1 : to validate the technical procedure, we will appreciate several parameters
Timeframe: up to 8 days after consent
2
Phase 2 : the primary outcome measures will be the maximum amplitude and the average amplitude of cerebral movements