Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease

Inclusion Criteria: * Diagnosis of Probable AD according to the National Institute on Aging- Alzheimer's Association (NIA-AA) guidelines (McKhann et al 2011). * MMSE score of 5 to 24 (inclusive) at the Screening Visit. * Has clinically significant agitation/aggression defined as Neuropsychiatric Inventory (NPI)-agitation/aggression subscore of ≥4. * No response or suboptimal response to standard nonpharmacological interventions. Exclusion Criteria: * The agitation/aggression is attributable to concomitant medications, environmental conditions, or active medical or psychiatric condition. * Current diagnosis of major depressive disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision (DSM IV TR). * Has persistent and distressing psychotic symptoms (delusion and/or hallucinations) that require psychiatric hospitalization.