Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study

Exclusion criteria

• . Significant neurologic disease such as Parkinson's disease, stroke, brain tumor, multiple sclerosis or seizure disorder.
• . Major depression in past 12 months (DSM-IV criteria), major mental illness such as schizophrenia, or recent (in past 12 months) alcohol or substance abuse by history.
• . History of invasive cancer within the past two years (excluding non-melanoma skin cancer).
• . Contra-indications to lumbar puncture (bleeding disorder, platelet count \< 100,000, anticoagulant treatment, major structural abnormality or sepsis in the area of the lumbosacral spine that would make spinal fluid collection technically difficult).
• . Clinically significant MRI abnormalities that contraindicate lumber or suggest central nervous system disease processes that could influence study outcomes in the opinion of the PI.
• . Use of any investigational agents within 30 days prior to screening.
• . Major surgery within eight weeks prior to the Baseline Visit.
• . Severe unstable medical illnesses, including uncontrolled cardiac conditions or heart failure (New York Heart Association Class III or IV) .