Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study (NCT01729598) | Clinical Trial Compass
CompletedEarly Phase 1
Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study
United States14 participantsStarted 2012-04
Plain-language summary
The purpose of this study is to evaluate the safety of administration and effects of valproic acid on clusterin expression in cognitively-intact, healthy, elderly subjects. Clusterin mutations have recently been identified as a risk factor for the development of Alzheimer's Disease and changes in clusterin expression are seen in the elderly who develop Alzheimer's disease irrespective of whether they carry these genetic mutations or not. Valproic acid may prevent or reverse these changes.
Fourteen subjects with normal memory and thinking will participate in this study. Ten of these subjects will receive valproic acid and 4 will receive a "placebo" capsule with no active medicine. Participants will take study medication or placebo for 28 days and be followed for a total 35 days in this trial.
Who can participate
Age range65 Years – 90 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Men or women aged 65-90, inclusive.
✓. English-speaking, to ensure compliance with cognitive testing and study visit procedures.
✓. Female participants must not be pregnant or of childbearing potential, i.e. either surgically sterile or postmenopausal for \> 1 year.
✓. Stable medical condition for three months prior to screening visit, with no clinically significant abnormalities of hepatic, renal, and hematologic function defined as follows:
✓. Stable medications for 4 weeks prior to screening visit.
✓. Able to ingest oral medications.
✓. No history of adverse drug reactions to VPA or similar agents.
✓. Physically acceptable for this study as confirmed by medical history, physical exam, neurological exam and clinical tests in the opinion of the study physician.
Exclusion criteria
✕. Significant neurologic disease such as Parkinson's disease, stroke, brain tumor, multiple sclerosis or seizure disorder.
What they're measuring
1
Frequency of Adverse Events Over the Duration of the Study by Study Arm
Timeframe: Day 35
2
Change in Cerebrospinal Fluid Amyloid Levels (pg/ml) Over 28 Day Intervention Period by Study Arm
✕. Major depression in past 12 months (DSM-IV criteria), major mental illness such as schizophrenia, or recent (in past 12 months) alcohol or substance abuse by history.
✕. History of invasive cancer within the past two years (excluding non-melanoma skin cancer).
✕. Contra-indications to lumbar puncture (bleeding disorder, platelet count \< 100,000, anticoagulant treatment, major structural abnormality or sepsis in the area of the lumbosacral spine that would make spinal fluid collection technically difficult).
✕. Clinically significant MRI abnormalities that contraindicate lumber or suggest central nervous system disease processes that could influence study outcomes in the opinion of the PI.
✕. Use of any investigational agents within 30 days prior to screening.
✕. Major surgery within eight weeks prior to the Baseline Visit.
✕. Severe unstable medical illnesses, including uncontrolled cardiac conditions or heart failure (New York Heart Association Class III or IV) .