Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers

Inclusion Criteria: * Age ≥ 18 years * Nulliparous (no previous pregnancy ≥ 22 SA) * Singleton pregnancy * Gestational age ≤ 15 +6 weeks * Bilateral uterine artery notch (grade ≥ 2) and/or bilateral uterine artery PI ≥ 1.7 during first trimester ultrasound (CRL between 45 and 84 mm) * Maternal informed consent obtained * Affiliated to social security system Exclusion Criteria: * Women considering voluntary pregnancy termination (≤ 14 weeks) * Pre-existing (maternal) indication for premature delivery before 37 weeks * Fetal condition detected during the first trimester scan (fetal malformation or nuchal translucency ≥ 95th percentile) * Women under anticoagulation * Allergy or hypersensitivity to Kardegic® or one of its constituents * Secondary hemostasis disorder responsible for bleeding or risk of bleeding * Peptic ulcer under evolution * Lupus or antiphospholipid syndrome