Muscle Atrophy in Patients With Severe Sepsis (NCT01717651) | Clinical Trial Compass
TerminatedNot Applicable
Muscle Atrophy in Patients With Severe Sepsis
Stopped: slow accrual made study completion unfeasible
United States25 participantsStarted 2011-12
Plain-language summary
This study is being done to help determine whether patients with severe sepsis (overwhelming inflammation in the body as a result of an infection) lose muscle and become weak more rapidly than patients with other severe illnesses. Weakness and muscle loss that develops after a severe illness is a serious problem. Patients who develop weakness and have a decrease in muscle size often have to stay in the hospital longer and have a higher chance of dying. At the current time, it is not clear whether certain severe illnesses are more likely to cause weakness and muscle loss. This study will be done to measure the changes in muscle size and strength as a result of each patient's illness
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥ 18 years
✓. Required mechanical ventilation for at least 24 hours
Exclusion criteria
✕. Ventilator liberation anticipated in the next 24 hours
✕. Known or suspected acute diagnosis of neuromuscular disease causing diffuse or lower extremity weakness (e.g. CVA, spinal cord injury or lesion, Muscular dystrophy, Myasthenia Gravis, GBS)
✕. Pre-existing lower extremity weakness caused by prior injury, neuromuscular or joint disease
✕. Wounds, dressings or injuries of the lower extremities or pelvis that prevent muscle testing or CPM
✕. Patient's family, physician, or both not in favor of aggressive treatment of patient that includes life-sustaining treatments or the presence of an advance directive indicating the same a. Rationale: Unlikely to survive to seven day endpoint
✕. More than seventy-two hours of continuous mechanical ventilation previously during this hospitalization
✕
What they're measuring
1
Quadriceps muscle cross sectional area change from day 0 to 7