UnknownNot Applicable

The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Israel40 participantsStarted 2013-01

Plain-language summary

The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging. Pepsin is a proteolytic enzyme present in the gastric juice. Microaspirations of gastric content were described as a potential factor for injury in many chronic lung disorders. Bronchoalveolar lavage (BAL) is a routine investigation technique in interstitial lung diseases. The presence of pepsin in the BAL fluid recovered from patients with IPF may indicate a possible role for gastric microaspirations in the pathogenesis of the disease.

Who can participate

Age range18 Years – 85 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients with interstitial lung disorders including IPF Exclusion Criteria: * patients younger than 18 years or older than 85, * pregnant women, * patients that present with medical conditions contra -indicated for performing bronchoscopy including sedation

What they're measuring

BAL Pepsin level

Timeframe: 18 MONTHS

Trial details

NCT IDNCT01714934

SponsorSheba Medical Center

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2014-06

View on ClinicalTrials.gov More IDIOPATHIC PULMONARY FIBROSIS trials