This study is designed to determine whether an oral perioperative medication (alvimopan--a selective mu antagonist) improves bowel recovery over placebo after surgery for ovarian cancer.
Who can participate
Age range18 Years
SexFEMALE
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Inclusion criteria:
* Females at least 18 years of age
* Have an American Society of Anesthesiologists (ASA) Score of I to III
* Are consented for primary, interval, or secondary cytoreduction for ovarian, tubal, or peritoneal cancer
* Are scheduled to have their nasogastric tube removed before the first postoperative dose of study medication
* Are able to understand the study procedures, have agreed to participate in the study program, and have voluntarily provided informed consent
Exclusion criteria:
* Females younger than 18 years of age
* Known non-gynecologic malignancy presenting with similar signs/symptoms as ovarian, tubal, or peritoneal cancer.
* Have taken more than 7 consecutive days of therapeutic doses of opioids immediately prior to surgery
* Use illicit drugs or abuse alcohol
* Have had a prior total colectomy, gastrectomy, gastric bypass, or have a functional colostomy or ileostomy
* Have an ongoing history of short bowel syndrome, chronic constipation (≤3 spontaneous bowel movements per week) or chronic diarrhea
* Have received radiation therapy to the abdomen or pelvis within 3 months of scheduled surgery
* Have chemotherapy or radiation induced bowel dysfunction
* Are pregnant (identified by a positive urine or serum pregnancy test) or lactating, or are not postmenopausal (no menses for at least 1 year) and are of childbearing potential and not using an accepted method of birth control (ie, surgical sterilization, intrauterine contraceptive device, oral …
What they're measuring
1
Postoperative Length of Hospital Stay
Timeframe: Patients will be followed for the duration of their hospital stay, an expected average of 5 days