Cromoglicate in Mastocytosis

Inclusion Criteria: * Signed informed consent has been obtained * Chronic stable symptomatic maculopapulous cutaneous mastocytosis or indolent systemic mastocytosis with skin involvement and a positive Darier's Sign * Age between 18 and 70 years * Either sex * Any race or ethnicity * Attending hospital outpatient clinic or the private practice of a dermatologist. Exclusion Criteria: * The presence of autoimmune and infectious disease including aggressive systemic mastocytosis * Medical history or presence of epilepsy, significant neurological disorders, cerebrovascular attacks or ischemia * Medical history or presence of myocardial infarction or cardiac arrhythmia which requires drug therapy, hyper/hypokalemia * Evidence of severe renal dysfunction (creatinine \> 1,5 times upper reference value) * Evidence of significant hepatic disease (liver enzymes \> 2 times upper reference value) * Presence of active cancer which requires chemotherapy or radiation therapy * Commitment to an institution in terms of § 40 Abs. 1 S. 3 Nr. 4 AMG * Intake of antihistamines or leukotriene antagonists within 7 days prior to the beginning of the study * Intake of oral corticosteroids within 14 days prior to randomisation * Use of depot corticosteroids or chronic systemic corticosteroids within 21 days prior to randomisation * Radiation therapy of target areas including UV therapy within 4 weeks prior to randomisation * Confounding other dermatological diseases or conditions that can affect the…