Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSD

Inclusion Criteria: * Diagnosed with chronic PTSD with a duration of 6 months or longer. * Have a CAPS score showing moderate to severe symptoms. * Had at least one unsuccessful attempt at treatment for PTSD, either with talk therapy or with drugs, or stopped treatment because of inability to tolerate psychotherapy or drug therapy. * Are at least 18 years old. * Generally healthy. * Must sign a medical release for the investigators to communicate directly with their therapist and doctors. * Are willing to refrain from taking any psychiatric medications during the study period. * Agree that, one week before the MDMA session, will refrain from taking all below unless with prior approval of research team: herbal supplements, nonprescription medications (with the exception of nonsteroidal anti-inflammatory drugs or acetaminophen, any prescription medications, with the exception of birth control pills, thyroid hormone, or other medications; * Are willing to follow restrictions and guidelines concerning consumption of food, beverages. and nicotine the night before and just prior to each experimental session. * Are willing to remain overnight at the study site. * Are willing to be contacted via telephone for all necessary telephone contacts. * Must have a negative pregnancy test if able to bear children, and agree to use an effective form of birth control. * Agree not to participate in any other clinical trial for the duration of this clinical trial, including the follow-up period.…