Efficacy and Safety of Influenza Vaccine During Sarcoidosis (NCT01687517) | Clinical Trial Compass
CompletedPhase 3
Efficacy and Safety of Influenza Vaccine During Sarcoidosis
France190 participantsStarted 2012-10
Plain-language summary
Sarcoidosis is an inflammatory disease of unknown origin that can affect all organs, especially the lungs and mediastinum. Some location of sarcoidosis may require treatment with corticosteroids or immunosuppressors.Although seasonal influenza vaccination can be recommended in sarcoidosis in some subgroups at risk (respiratory failure, pulmonary fibrosis, age over 65, use of immunosuppressive therapy, etc ...), the investigators presently have no data on the efficacy and safety (absence of adverse reactions) of seasonal influenza vaccination in sarcoidosis.Especially it is not known whether the seasonal influenza vaccine provides the same rate and same type of vaccine response in sarcoidosis patients than in the general population. Similarly, it is unclear whether the vaccine response is modified by the severity of the disease and treatment with corticosteroids and immunosuppressors.Based on what is known in systemic lupus and rheumatoid arthritis, which are both inflammatory and autoimmune diseases, the investigators expect at best a 50% vaccine response in patients with sarcoidosis and a 85% vaccination response in healthy controls. The demonstration of a vaccine response could allow reconsidering new vaccine approaches in sarcoidosis.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria for patients:
* Age ≥ 18 and ≤ 65;
* Signature of informed consent
* Follow-up : six months following the influenza vaccination at D0
* Sarcoidosis diagnosed and histologically proven since at least 6 months
* unchanged treatment of Sarcoidosis for at least 3 months, except for the case of a decrease in doses of corticosteroids and at a stable dose of immunosuppressive drugs
* Indication for a seasonal influenza vaccination.
Existence of one or more of these clinical situations:
* pulmonary location (dyspnea, radiological or stage IV pulmonary function tests (PFT) altered with decreased forced vital capacity (FVC), forced expiratory volume average (FEV) or the diffusion of carbon monoxide (TLCO) below 65% of predicted value;
* Cardiac impairment confirmed
* Central nervous system impairment and / or device and confirmed with clinical impact and abnormal imaging and / or electromyogram- Renal impairment (histologically confirmed) responsible for a decrease in creatinine clearance
* disabling Lupus pernio
* Sinuso-nasal and / or laryngeal impairment histologically confirmed
* Disseminated impairment, ie affecting more than four organs
* Dose of corticosteroids ≥to 10 mg per day of the equivalent of prednisone or the necessity of an immunosuppressive therapy (with the exception of Rituximab) to control sarcoidosis- Existence of an associated metabolic disorder
* Patients with sarcoidosis and living in a care house
* Sarcoidosis occurring in health/nursing s…