Multicenter Trial Evaluating the Immunogenicity of HPV Vaccination in Girls on Immunosuppressive Therapy.

Inclusion Criteria: * Female gender * Age ≥ 9 years and \< 18 years * Weight ≥ 25 kg * Solid organ transplantation: kidney, liver, heart, lung, intestinal or combined transplant; or systemic lupus erythematosus or other systemic immune disease * Transplantation or diagnosis of lupus or diagnosis of systemic immune disease since more than 6 months * Immunosuppressant treatment by anti-metabolites or calcineurin inhibitors, with or without associated corticosteroids * Minimum required period of 3 months considered as stable after transplantation or without relapse of lupus according to physician evaluation * In case of sexual activity (assessed by auto-declaration): onset less than one year before inclusion * Written informed consent signed by the investigator and the legal representatives of the patient, and assent by the patient Exclusion Criteria: * Male gender * Pregnancy * Age \< 9 years or ≥ 18 years * Previous HPV vaccination * Immunosuppressive treatment by anti-TNF (adalimumab, etanercept, infliximab) or monoclonal antibodies (rituximab, anakinra, abatacept) during the last 3 months * Active malignancy * Active opportunistic infection * HIV infection * Concurrent clinical trial