A Study, Performed in Subjects With Post Traumatic-post Surgical ,Venus Insufficiency and Diabetic Hard to Heal/Chronic Wounds, to Evaluate the Safety and Efficacy of PolyHeal-2 Versus PolyHeal in Once Daily Regimen

Inclusion Criteria: * Hard to heal/chronic post traumatic post surgical ,venus insufficiency and diabetic wound refractory to healing at least 4 weeks prior to study treatment (one or more target wound/s will be eligible per each subject to be treated by the same agent) * Subjects who are able to read, understand, and sign the informed consent form. In case of compromised mental capacity, approval and signature of a legal guardian is required. Exclusion Criteria: * Presence of a systemic infection or significant local infection with copious purulent drainage, fluids drainage, gangrene, or cellulites, or necrosis at the target wound site, as well as nonviable tissue, sinus tracts or tunnels that cannot be removed by debridement. * Wounds with exposed bones, tendons or ligaments * Wounds with exposed orthopedic implants * Wounds with exposed breast prostheses * Uncontrolled diabetes with HbA1c \>11% * Subjects with BMI greater than 35kg/m2 * Woman who are pregnant or nursing, or of childbearing potential and are not using adequate contraception * Participation in another clinical drug/device trial within 30 days prior to the Screening visit or during this study