Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents (NCT01665742) | Clinical Trial Compass
CompletedNot Applicable
Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents
Ireland58 participantsStarted 2012-01
Plain-language summary
The number of overweight and obese children has increased in Ireland at a greater rate than worldwide trends. The poor eating patterns that drive adolescent obesity leads to an increase in the number of unhealthy inflammatory hormones and fats circulating in the blood which increase an adolescent's risk of developing diabetes and heart disease later in life. Dietary patterns have changed whereby key nutrients that are found in fruit, vegetables and fish, which are known to have beneficial effects and reduce risk of obesity and diabetes in later life, may need to be replaced. This project will determine whether a key anti-inflammatory nutrient supplement taken for 8 weeks will improve the metabolic profile of adolescents aged 13-18 years old. Detailed cellular analysis will determine the cellular and molecular mechanisms to provide a thorough explanation of the health effects of this intervention.
Who can participate
Age range13 Years – 18 Years
SexALL
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Inclusion criteria
✓. Male or female
✓. 13-18 years
✓. Body mass index ≥ 91st percentile on UK growth reference charts (Cole, 1995)
✓. Medications/dietary supplements which do not interfere with the intervention are allowed, on condition that the participants adhere to the same regimen during the intervention, including oral contraceptives and other non-fatty acid based dietary supplements (e.g. garlic)
✓. Smoker or non-smoker
✓. Not participating in any other intervention study
Exclusion criteria
✕. Pregnancy or lactation
✕. Endocrine disorders such as Polycystic Ovary Syndrome
✕. Currently on treatment for a chronic inflammatory condition such as asthma
✕. Kidney or liver dysfunction
What they're measuring
1
Homeostasis model of assessment - insulin resistance