The purpose of this study was to assess the safety and describe the steady-state plasma pharmacokinetic (PK) profiles of Travoprost ophthalmic solution, 0.004% (new formulation) following a once daily administration for 7 days in pediatric glaucoma or ocular hypertension patients.
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Maximum Observed Travoprost Free Acid Plasma Concentration (Cmax)
Timeframe: Day 7, Up to 80 minutes postdose
Time to Reach Cmax (Tmax)
Timeframe: Day 7, Up to 80 minutes postdose
Time to Last Measurable Concentration (Tlast)
Timeframe: Day 7, Up to 80 minutes postdose
Area Under the Analyte Plasma Concentration-time Curve to the Last Quantifiable Sampling Time Point [AUC(0-tlast)]
Timeframe: Day 7, Up to 80 minutes postdose
Area Under the Analyte Plasma Concentration-time Curve Over the Dosing Interval (Inf)[AUC(0-∞)]
Timeframe: Day 7, Up to 80 minutes postdose
Half-life (t½)
Timeframe: Day 7, Up to 80 minutes postdose